This repository contains preprocessed data files and trained model files associated with the manuscript "A systematic evaluation of deep learning methods for the prediction of drug synergy in cancer". The preprocessed data files include the preprocessed drug response dataset, filtered gene expression, mutation and CNV files (before merging with the response dataset), and the fully preprocessed drug and gene expression data required for the exprDGI + drugsECFP4 model described in the study.This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UIDB/04469/2020 unit and through a PhD scholarship (SFRH/BD/130913/2017) awarded to Delora Baptista
Motivation: Accurate and robust drug response prediction is of utmost importance in the realm of pre...
## GDSC dataset **GDSC_EXP.csv** GDSC gene expression profiles for 966 cancer cell lines, where eac...
A major challenge in cancer treatment is predicting clinical response to anti-cancer drugs on a pers...
This repository contains preprocessed data files, trained model files, and SHAP results associated w...
Predicting the sensitivity of tumors to specific anti-cancer treatments is a challenge of paramount ...
Abstract Background The study of high-throughput genomic profiles from a pharmacogenomics viewpoint ...
While synergistic drug combinations are more effective at fighting tumors with complex pathophysiolo...
One of the main obstacles to the successful treatment of cancer is the phenomenon of drug resistance...
Cancers are genetically heterogeneous, and therefore the same anti-cancer drug may have varying degr...
A mishap in anti-cancer drug distribution is critical in breast cancer patients due to poor predicti...
The lack of a gold standard synergy quantification method for chemotherapeutic drug combinations war...
The lack of a gold standard synergy quantification method for chemotherapeutic drug combinations war...
In this project, a novel computational method based on deep learning algorithm was successfully deve...
Most drugs entering clinical trials fail, often related to an incomplete understanding of the mechan...
Motivation: While drug combination therapies are a well-established concept in cancer treatment, ide...
Motivation: Accurate and robust drug response prediction is of utmost importance in the realm of pre...
## GDSC dataset **GDSC_EXP.csv** GDSC gene expression profiles for 966 cancer cell lines, where eac...
A major challenge in cancer treatment is predicting clinical response to anti-cancer drugs on a pers...
This repository contains preprocessed data files, trained model files, and SHAP results associated w...
Predicting the sensitivity of tumors to specific anti-cancer treatments is a challenge of paramount ...
Abstract Background The study of high-throughput genomic profiles from a pharmacogenomics viewpoint ...
While synergistic drug combinations are more effective at fighting tumors with complex pathophysiolo...
One of the main obstacles to the successful treatment of cancer is the phenomenon of drug resistance...
Cancers are genetically heterogeneous, and therefore the same anti-cancer drug may have varying degr...
A mishap in anti-cancer drug distribution is critical in breast cancer patients due to poor predicti...
The lack of a gold standard synergy quantification method for chemotherapeutic drug combinations war...
The lack of a gold standard synergy quantification method for chemotherapeutic drug combinations war...
In this project, a novel computational method based on deep learning algorithm was successfully deve...
Most drugs entering clinical trials fail, often related to an incomplete understanding of the mechan...
Motivation: While drug combination therapies are a well-established concept in cancer treatment, ide...
Motivation: Accurate and robust drug response prediction is of utmost importance in the realm of pre...
## GDSC dataset **GDSC_EXP.csv** GDSC gene expression profiles for 966 cancer cell lines, where eac...
A major challenge in cancer treatment is predicting clinical response to anti-cancer drugs on a pers...